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Modulation of Immune Response
Author(s) -
Dean Dwane H.,
Hiramoto Raymond N.,
Ghanta Vithal K.
Publication year - 1987
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1987.58.7.498
Subject(s) - immune system , saliva , epidermal growth factor , in vitro , periodontium , nerve growth factor , spleen , immune modulation , immunology , biology , chemistry , endocrinology , medicine , receptor , dentistry , biochemistry
Both epidermal growth factor (EGF) and nerve growth factor (NGF) were found to moderate the reactivity of mouse spleen cells in an in vitro model of immune response. Blastogenic response was suppressed by EGF and potentiated by NGF. Both proteins are present in mouse, but not human, saliva in quantities equal to or greater than those affecting blastogenic response in our assay. Immune response occurring in the mouse periodontium may be affected by the presence of these factors in the saliva.