Hydrogen Peroxide Inhibits Glucose Metabolism and Collagen Synthesis in Bone | Zendy

Ramp Warren K. | Zendy; Arnold Roland R. | Zendy; Russell James E. | Zendy; Yancey John M. | Zendy

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Hydrogen Peroxide Inhibits Glucose Metabolism and Collagen Synthesis in Bone

Author(s) -

Ramp Warren K.,

Arnold Roland R.,

Russell James E.,

Yancey John M.

Publication year - 1987

Publication title -

journal of periodontology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.036

H-Index - 156

eISSN - 1943-3670

pISSN - 0022-3492

DOI - 10.1902/jop.1987.58.5.340

Subject(s) - hydrogen peroxide , carbohydrate metabolism , metabolism , chemistry , biochemistry , endocrinology , medicine , dentistry

Effects of H 2 O 2 on bone were evaluated in an organ culture system. Tibiae from chick embryos were incubated for up to 3 days in culture medium containing 0.07 to 20 mM H 2 O 2 . Glucose metabolism was monitored by measuring lactate production and oxygen consumption, and collagen synthesis was determined by hydroxylation of proline. In addition to markedly inhibiting these parameters, H 2 O 2 also decreased bone weight and alkaline Phosphatase activity. Multiple exposures to H 2 O 2 were somewhat more effective than a single exposure. Since H2O2 inhibits bone at low concentrations in vitro , the results suggest that the potential for harmful effects of H 2 O 2 in the oral cavity should be investigated.

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