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Antibodies to Actinobacillus actinomycetemcomitans in a Korean Population
Author(s) -
Chung ChongPuoung,
Lee YoungKwan,
Choi SangMook,
Nisengard Russell J.
Publication year - 1986
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1986.57.8.510
Subject(s) - actinobacillus , antibody , serotype , population , juvenile , immunology , aggressive periodontitis , medicine , biology , periodontitis , environmental health , genetics
Previous studies demonstrated that serum antibodies to Actinobacillus actinomycetemcomitans strain Y4 are significantly elevated in sera from localized juvenile periodontitis (LJP) and postlocalized juvenile periodontitis (P‐LJP) patients compared to normal controls in United States populations. This study examined the age of subjects in relation to the antibody levels to A. actinomycetemcomitans in a Korean population. Seven groups were investigated including sera from newborns, infants, children, periodontally normal puberty and adult groups and LJP and P‐LJP groups. Antibody levels were determined by an enzyme‐linked immunosorbent assay (ELISA) to A. actinomycetemcomitans strain SNUDC 10–1 (serotype C) isolated from a Korean LJP patient. In the healthy non‐LJP and non‐P‐LJP subjects, IgG levels decreased from the newborn group to the 5‐month‐old group and then gradually increased through the adult group. The IgM levels in these groups continuously increased from birth until a plateau was reached in the 2‐ to 6‐year group. Serum IgA levels to strain SNUDC 10–1 were too low to be measured by this assay.