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Effects of Hydrogen Peroxide on Oral Carcinogenesis in Hamsters
Author(s) -
Weitzman Sigmund A.,
Weitberg Alan B.,
Stossel Thomas P.,
Schwartz Joel,
Shklar Gerald
Publication year - 1986
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1986.57.11.685
Subject(s) - dmba , hydrogen peroxide , carcinogen , benzanthracene , carcinogenesis , chemistry , pathology , dysplasia , benzoyl peroxide , medicine , cancer research , cancer , biochemistry , organic chemistry , polymerization , polymer
The effects of twice weekly topical applications of hydrogen peroxide on the buccal epithelium of Syrian hamsters were studied. Animals were treated either with hydrogen peroxide alone, with hydrogen peroxide and the carcinogen 9, 10‐dimethyl‐l,2‐benzanthracene (DMBA), or with DMBA alone. In animals treated with 30% H 2 O 2 alone, histopathologic examination after 22 weeks revealed hyperkeratosis and hyperplasia in all animals with hyperchromatic cells and mild dysplasia in four of nine: no tumors were seen. In animals treated with DMBA alone, three of seven (43%) developed epidermoid carcinoma, while six of 11 (55%) of animals treated with DMBA plus 3% hydrogen peroxide and five of five (100%) of animals treated with DMBA plus 30% hydrogen peroxide ( P = 0.054) developed carcinoma. Thus, hydrogen peroxide can, by itself, induce pathologic changes frequently associated with preneoplastic lesions; it may also augment carcinogenesis associated with DMBA.