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Arachidonic Acid Metabolism in Inflamed Gingiva and its Inhibition by Anti‐Inflammatory Drugs
Author(s) -
ElAttar Tawfik M. A.,
Lin Hsien S.,
Tira Daniel E.
Publication year - 1984
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1984.55.9.536
Subject(s) - piroxicam , ibuprofen , flurbiprofen , arachidonic acid , pharmacology , chemistry , cyclooxygenase , anti inflammatory , metabolism , inflammation , periodontitis , nonsteroidal , mefenamic acid , enzyme , medicine , biochemistry , pathology , alternative medicine
P rostaglandin (pg) synthetase inhibitors are tissue‐selective. Therefore, the action of four nonsteroidal anti‐inflammatory drugs (NSAID) was tested against PG synthesis from 14 C‐arachidonic acid by gingival homogenate. Suprofen and tolmetin sodium did not significantly inhibit PGs at any of the three concentration levels used (10 −7 , 10 −5 , 10 −3 m), whereas flurbiprofen and zomepirac sodium did significantly inhibit PG formation at millimolar concentration. The results, coupled with our previous study on indomethacin, Piroxicam and Ibuprofen open the way for future tests of NSAIDs in treatment of gingival inflammation and periodontal disease.