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Salivary Immunoglobulins in Patients With Juvenile Periodontitis and Their Healthy Siblings
Author(s) -
Sandholm Leena,
Grönblad Eva
Publication year - 1984
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1984.55.1.9
Subject(s) - juvenile , periodontitis , antibody , medicine , saliva , dentistry , immunoglobulin a , immunology , immunoglobulin g , biology , genetics
T he concentrations of the salivary immune‐globulins IgA, IgG and IgM were determined with a solid phase radioimmunoassay in the unstimulated whole saliva of 21 patients with juvenile periodontitis (JP), their 27 healthy siblings and 17 healthy age‐matched controls. In the JP group the concentrations of IgA were increased, averaging 188 ± 32.5 (SE) mg/L as compared with the mean of 139 ± 21.2 mg/L in their healthy siblings and 130 ± 24.5 mg/L in the controls. An elevation was found in the amount of IgG in the JP patients: 45.6 ± 12.5 mg/L as compared with 18.1 ± 5.9 mg/L in the siblings and 21.0 ± 5.6 mg/L in the controls. The mean IgM was 22.5 ± 5.4 mg/L in the JP group, 13.3 ± 2.9 mg/L in the siblings and 8.7 ± 1.6 mg/L in the controls, indicating an increase of IgM in the JP group and the siblings. A significant difference was found in the mean IgM values in the juvenile periodontitis group when compared to the control group. (0.02 > P > 0.01).