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Tetracycline and Its Derivatives Strongly Bind to and Are Released From the Tooth Surface in Active Form
Author(s) -
Baker P. J.,
Evans R. T.,
Coburn R. A.,
Genco R. J.
Publication year - 1983
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1983.54.10.580
Subject(s) - actinomyces naeslundii , spiramycin , minocycline , tetracycline , chemistry , in vitro , actinomyces , microbiology and biotechnology , antibiotics , streptococcus mutans , saliva , oxytetracycline , antimicrobial , adsorption , dental plaque , bacteria , erythromycin , biochemistry , biology , organic chemistry , genetics
S everal antibiotics were found to adsorb to saliva‐coated enamel and to inhibit in vitro plaque formation by pure cultures of oral bacteria: Actinomyces viscosus, Actinomyces naeslundii and Streptococcus mutans. Tetracycline, minocycline and oxytetracycline adsorbed to the greatest degree, showing 100‐fold higher adsorption than spiramycin, the test antibiotic with least adsorption. Inhibition of in vitro plaque formation was found to require both drug substantivity (capacity for adsorption) and antimicrobial activity. Inhibition of plaque formation in the in vitro assay employed correlated well with clinical efficacy.