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Experimental Periodontal Disease: Immediate Hypersensitivity ,
Author(s) -
Asaro John P.,
Nisengard Russell,
Beutner Ernst H.,
Neiders Mirdza
Publication year - 1983
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1983.54.1.23
Subject(s) - antigen , periodontium , delayed hypersensitivity , hypersensitivity reaction , histopathology , medicine , periodontal disease , disease , immunology , pathology , dentistry
I mmediate hypersensitivity reactions were induced in the periodontium and skin of monkeys sensitized with novo alcalase. Animals were challenged in the gingival papillae with 0.1, 1.0, and 10 μ g of antigen for 1, 3, 5, or 7 consecutive days prior to sacrifice. At the same time, skin sites were challenged with 1 μ g of antigen. With repetitive immediate hypersensitivity reactions, the inflammatory infiltrate changed from one characterized by polymorphonuclear leukocytes to one characterized by plasma cells and lymphocytes. The repetitive gingival exposure to bacterial antigens which occur in periodontal disease could lead to repetitive immediate hypersensitivity reactions. Such reactions could play a role in the histopathology of human periodontal disease.