Premium
Effect of Peptide Extracted From Skeletal Muscles of the Fur Seal on Periodontal Diseases
Author(s) -
Hiyama Eiji,
Matsui Toshiyuki,
Kamo Tsunekazu,
Kaneko Keiko,
Ito Haruo
Publication year - 1982
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1982.53.10.639
Subject(s) - vasodilation , peptide , medicine , pharmacology , chemistry , biochemistry
I t has been confirmed previously that a physiologically active peptide extracted from the skeletal muscles of fur seals exhibits excellent dermal absorption and has peripheral vasodilating properties. These properties were postulated to be beneficial to inflamed periodontal tissues. To test this, a dentifrice containing the peptide was prepared and utilized in a doubleblind test. Significant improvement in the gingival conditions was observed when a 0.1% or more concentration of peptide was used. As time progressed, distinct clinical improvement in redness, swelling, drainage, bleeding and pocket depth was noted. No significant side effects were noted although there were seen increased salivation and gingival blanching. It is believed, as a result of this and other studies, that the clinical efficacy of this peptide is due to its vasodilating action on the venules, thus reducing the internal pressure in the vascular beds.