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Nuclear Uptake of Sex Steroids in Gingiva of the Baboon
Author(s) -
Aufdemorte Thomas B.,
Sheridan Peter J.
Publication year - 1981
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1981.52.8.430
Subject(s) - periodontium , baboon , hormone , endocrinology , medicine , receptor , steroid , sex hormone receptor , dihydrotestosterone , lamina propria , biology , sex steroid , steroid hormone , estrogen receptor , androgen , epithelium , dentistry , genetics , cancer , breast cancer
I nfluences of sex steroid hormones on the periodontium are documented. Confirmation of the presence and location of receptors for these hormones is important in achieving a more complete understanding of their role in periodontal disease. Biochemical studies have provided evidence of sex steroid receptors in cytosols prepared from gingival tissues, however, no morphologic data are available on the location or specific cell types with receptors. For this study, three mature male and three female baboons received tritiated 5‐ α ‐dihydrotestosterone ( 3 H‐DHT) while three similar males and three females received tritiated estradiol‐ β ( 3 H‐E 2 ). A control animal from each group of three was given an excess of the corresponding unlabeled hormone in addition to the tritiated dose. Gingival specimens were obtained at necropsy as part of a total body study of receptor distribution, and autoradiographs were prepared on emulsion‐coated slides. Heavy nuclear uptake was observed in periosteal fibroblasts and scattered fibroblasts of the lamina propria in males given 3 H‐E 2 . Females had moderate uptake of E 2 in similar but fewer sites than males. There was minimal uptake of 3 H‐DHT in one male and two females. These data provide additional evidence of steroid receptors in the periodontium and contribute to our understanding of responses of the periodontium to sex steroids.