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Comparison of Neutrophil Chemotactic Response in Diabetic Patients With Mild and Severe Periodontal Disease
Author(s) -
ManouchehrPour M.,
Spagnuolo P. J.,
Rodman H. M.,
Bissada N. F.
Publication year - 1981
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1981.52.8.410
Subject(s) - medicine , chemotaxis , periodontitis , diabetes mellitus , clinical attachment loss , periodontal disease , gastroenterology , gingival and periodontal pocket , dentistry , inflammation , endocrinology , receptor
T his study was undertaken to evaluate the relationship between the severity of periodontitis and neutrophil (PMN) chemotactic abnormalities in diabetic patients and to correlate the observed PMN chemotactic defects with the degree of gingival inflammation and the amount of periodontal attachment loss. Fourteen dentulous, insulin‐dependent, adult onset diabetics and 18 nondiabetics participated in this study. Complete periodontal examinations including periodontal charting and full mouth radiography were performed, and gingival and plaque indices were recorded. Severe periodontitis was diagnosed in eight diabetics and seven nondiabetics. The remainder of the subjects including six diabetic patients and 11 nondiabetic subjects demonstrated mild or no periodontal disease and served as controls. The chemotactic assay employed a modification of the Boyden technique. Chemoattractants studied included endotoxin activated autologous plasma, endotoxin activated normal plasma, and n‐formylmethionyl‐leucyl‐phenylalanine. The results indicated that diabetic patients with severe periodontitis had lower PMN chemotactic response than diabetic subjects with mild periodontal disease and nondiabetic subjects with either mild or severe periodontitis, regardless of chemoattractant studied. There were no significant differences between the mean PMN chemotactic indices of diabetic patients with mild periodontal disease and nondiabetic patients with either mild or severe periodontitis. There was no correlation between chemotactic index, periodontal attachment loss and gingival index in diabetics or nondiabetics. Based on previous reports of the association between impaired PMN chemotaxis and periodontal destruction in some forms of periodontal disease and the significant impairment of PMN chemotaxis we have observed in diabetic patients with severe periodontitis, it is possible that altered PMN chemotaxis may contribute to the severity of periodontitis in diabetics.