Premium
Serum α ‐1‐Antitrypsin in Patients With Juvenile Periodontitis
Author(s) -
Sandholm Leena,
Saxén Leena,
Koistinen Jukka
Publication year - 1981
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1981.52.6.321
Subject(s) - juvenile , periodontitis , medicine , dentistry , microbiology and biotechnology , biology , genetics
α ‐1‐A ntitrypsin phenotypes and serum levels were determined in 19 patients with juvenile periodontitis in order to test whether reduced periodontal resistance in this disease is caused by decreased serum protease inhibitory capacity resulting from deficient α ‐1‐antitrypsin phenotypes. The phenotyping of the patients' sera was performed by thin‐layer isoelectric focusing in polyacrylamide gel. The quantitation of α ‐1‐antitrypsin was performed using the radial immunodiffusion technique. All 19 patients displayed the most common phenotype M. Twelve patients had the subclass M 1 M 1 , two the M 1 M 2 and five the M 1 M 3 . The α ‐1‐antitrypsin levels in the patients' sera were within normal limits. The results do not support the hypothesis that deficient production of α ‐1‐antitrypsin is causally related to juvenile periodontitis.