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Diabetes and Periodontal Disease ‐‐ Possible Role of Vitamin C Deficiency: An Hypothesis
Author(s) -
Aleo Joseph J.
Publication year - 1981
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1981.52.5.251
Subject(s) - ascorbic acid , diabetes mellitus , vitamin c , medicine , histamine , endocrinology , disease , ascorbic acid deficiency , periodontal disease , vitamin , biology , food science
A n hypothesis is proposed relating the possible role of vitamin C deficiency as an etiologic factor contributing to periodontal disease in diabetes. The hypothesis is based upon the following: (1) transport of ascorbate across cell membranes may be impaired by glucose, but facilitated by insulin; (2) glucose utilization is significantly accelerated by sublethal concentrations of endotoxin; (3) endotoxin‐induced histamine sensitivity of tissue is enhanced by ascorbic deficiency; and (4) ascorbic acid deficiency alters mucosal barrier function. The interrelationship of these factors is discussed.