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Immunological Comparison of Plaque‐Resistant and Plaque‐Susceptible Inbred Rat Strains
Author(s) -
Ito Nobuyoshi,
Mergenhagen Stephan E.,
Rosenstreich David L.
Publication year - 1981
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1981.52.4.190
Subject(s) - inbred strain , biology , microbiology and biotechnology , virology , genetics , gene
A n immunological comparison of ODU Plaque‐Resistant (RES) and Plaque‐Susceptible (SUS) Rats was performed in order to determine if plaque accumulation was secondary to some immunological abnormality, and to ascertain the effects of plaque accumulation on the immune system. Plaque accumulation in SUS rats on powder diets is associated with a significant elevation in immunoglobulin levels over RES rats, especially in serum IgG and IgM. Young (< 9 weeks) SUS rats possess fewer splenic T lymphocytes than do young RES rats. This decrease is associated with a marked decrease in the response of spleen cells in vitro to T cell mitogens, Con A and PHA. This decrease is unrelated to diet and is completely and spontaneously reversed in the adult (3 month) rats. These studies demonstrate that the accumulation of large amounts of plaque cause an elevation in immunoglobulin levels. However, plaque accumulation in SUS rats does not appear to be secondary to any demonstrable immunologic abnormality.