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Tetracycline: Levels Achievable in Gingival Crevice Fluid and in Vitro Effect on Subgingival Organisms: Part I. Concentrations in Crevicular Fluid After Repeated Doses
Author(s) -
Gordon J. M.,
Walker C. B.,
Murphy J. C.,
Goodson J. M.,
Socransky S. S.
Publication year - 1981
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1981.52.10.609
Subject(s) - tetracycline , chemistry , medicine , body fluid , dentistry , anesthesia , antibiotics , biochemistry
T he concentration of tetracycline in gingival crevice fluid and blood was determined using a sensitive bioassay after oral administration of repeated doses of tetracycline. Crevicular fluid was sampled by an intracrevicular technique from four gingival sites in each individual and blood was obtained by finger puncture. Four volunteers received doses of 250 mg of tetracycline‐HCl either every 6 hours or every 12 hours and were sampled at hours 0 to 15, 21 to 36, 48 to 60 and 96 to 102. Volunteers given 250 mg every 6 hours had average crevicular fluid concentrations between 4 to 8 μ g/ml and blood concentrations between 2 to 2.5 μ g/ml after 48 hours. The levels in crevicular fluid and blood of volunteers who received 250 mg every 12 hours were 2 to 4 μ g/ml and 0.3 to 1.4 μ g/ml respectively after 48 hours. The results demonstrated that after repeated doses of tetracycline the crevicular fluid levels were typically 2 to 4 times the blood levels.