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The Effect of Levamisole on Experimental Gingivitis in the Beagle Dog
Author(s) -
Bratthall Gunilla,
Magnusson Ingvar,
Lindhe Jan
Publication year - 1980
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1980.51.6.331
Subject(s) - beagle , gingivitis , levamisole , junctional epithelium , connective tissue , dentistry , gingival margin , medicine , pathology
T he effect of Levamisole on gingivitis development was studied in three beagle dogs. Plaque accumulation was first allowed on one side of the jaws whereas the other side was subjected to careful tooth cleaning procedures. After 2 weeks' experimental gingivitis the dogs were given Levamisole and plaque accumulation was permitted on the other side of the jaws for another two weeks. The following parameters were investigated in the two gingivitis experiments: Plaque and Gingival Indices, Gingival Exudate measurements and histologic measurements. The biopsies were prepared both for light and electron microscopy. The clinical parameters did not show any differences between the two gingivitis experiments. The biopsies, however, demonstrated a larger area of infiltrated connective tissue and an increased number of leukocytes in the junctional epithelium in Levamisole‐treated compared to normal animals.