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Insulin I 125 Distribution Within Oral Tissues
Author(s) -
Pourdeihimi Bahram,
Keene Joseph J.,
Gargiulo Anthony W.,
Toto Patrick D.
Publication year - 1980
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1980.51.4.199
Subject(s) - insulin , medicine , endocrinology , distribution (mathematics) , thyroid , tissue distribution , chemistry , mathematical analysis , mathematics
T he localization of insulin I 125 in oral tissues of the rat was investigated. Eight rats were made chemically diabetic in order to study the tissue distribution of insulin I 125 . Two nondiabetic control animals were also injected with the tracer. Another animal served as a complete control (i.e., not injected with either the diabetic inducer or insulin I 125 ). Additional controls were sections of thyroid and liver. Experimental rats were sacrificed at preselected time intervals and autoradiographic procedures were performed subsequent to conventional histologic studies. Qualitative grain counts were made of each slide in order to compare with the background count. All oral tissues studied except dentin showed insulin I 125 uptake.