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Osteopoietin—Humoral Induction Factor in Osteogenesis
Author(s) -
Amler Melvin H.,
Gold William
Publication year - 1980
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1980.51.4.185
Subject(s) - regeneration (biology) , bone marrow , cell , chemistry , glycoprotein , biophysics , bone formation , biomedical engineering , materials science , microbiology and biotechnology , biology , immunology , biochemistry , endocrinology , medicine
A heat‐stable , glycoprotein‐like material, osteopoietin, produced during bone marrow regeneration, has been shown to induce bone formation when implanted in the rat eye. The material was separated by ultrasonic treatment or by acid buffer (pH 3–5) from sponges implanted in the marrow. The extracted material free of bone or cell solids, induced bone formation in the anterior eye chamber of the rat, whereas the cell solids and control sponges similarly implanted did not.