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Lyophilized Bone Allografts in Periodontal Intraosseous Defects
Author(s) -
Altiere Eugene T.,
Reeve Charles M.,
Sheridan Phillip J.
Publication year - 1979
Publication title -
journal of periodontology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1979.50.10.510
Subject(s) - medicine , curettage , dentistry , transplantation , radiography , periodontal surgery , human bone , surgery , bone grafting , bone transplantation , regeneration (biology) , biochemistry , chemistry , in vitro , biology , microbiology and biotechnology
Nine patients with 10 pairs of intraosseous periodontal defects were treated. Most of the patients had identical bilateral lesions (referred to as "mirror-image" defects). In each pair, one of the defects was randomly selected and treated as a flap and currettage control whereas the other defect was grafted with freeze-dried cortical powdered allografts of bone. Evaluation was based on radiographs, photographs, and measurements taken during both the initial surgery and at reentry approximately 1 year after transplantation. Control procedures (flap and curettage) demonstrated the same amount of osseous regeneration as that seen with the graft procedure. The amount of osseous regeneration demonstrated with the grafting procedures agreed with previously published studies. Evaluation revealed that (1) an autologous control such as incorporated in the "mirrow-image" design of this study is probably the most valid experimental model available for evaluating the clinical effectiveness of any human periodontal grafting procedures; (2) the effectiveness of freeze-dried cortical powdered bone allografts in human periodontal osseous defects is questionable and needs additional study; and (3) nongrafting procedures may be more effective in generating new attachments or reattachments in human periodontal osseous defects than previously believed.