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Effect of Chlorhexidine Gluconate on Acute Nonmicrobial Inflammation Reaction
Author(s) -
Knuuttila Matti L. E.,
Paunio Keijo U.,
Mielityinen Helena
Publication year - 1978
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1978.49.2.96
Subject(s) - periodontology , medicine , dentistry , library science , university hospital , family medicine , computer science
The effects of chlorhexidine on the appearance of leukocytes and some hydrolytic enzymes were studied in an experimental acute nonmicrobial inflammation reaction caused by implanation of viscose sponge beneath the backskin. The results showed that chlorhexidine gluconate decreased the number of leukocytes in the inflammatory exudate. The drug used had no measurable effect on the distribution of different types of leukocytes. Chlorhexidine has a clear inhibitory effect on the appearance of phosphatases, glycosidases and peptidases. On the other hand the effect on proteinases was small.