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An in Vivo Comparison of Chlorhexidine and Picloxydine Mouthrinses: A Possible Association Between Chemical Structure and Antiplaque Activity
Author(s) -
Newcomb G. M.,
McKellar G. M.,
Rawal B. D.
Publication year - 1977
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1977.48.5.282
Subject(s) - bequest , chlorhexidine , association (psychology) , library science , pharmacy , dentistry , medicine , psychology , family medicine , computer science , political science , law , psychotherapist
A double blind clinical trial was conducted in which both the plaque-inhibiting ability and the in vivo effects on the oral flora of chlorhexidine and picloxydine mouthwashes was compared. While picloxydine in higher concentration suppressed the oral flora more effectively than chlorhexidine, the latter agent inhibited plaque development to a much greater extent. This lack of correlation between antibacterial and antiplaque activity can be related to structural differences between these two bis-biguanides.