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Effects of Scleral Collagen upon the Healing of Experimental Osseous Wounds
Author(s) -
Mositow Bernard S.,
Gold Steven I.,
Gottsegen Robert
Publication year - 1976
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.1976.47.10.596
Subject(s) - sclera , medicine , wound healing , connective tissue , histology , implant , tendon , achilles tendon , surgery , dentistry , pathology
Standardized wounds were created in the femurs of 13 female white New Zealand rabbits and implanted with autogenous scleral connective tissue, Achilles bovine tendon collagen chips and cores of cancellous autogenous bone and marrow. A blood-filed wound served as a control. The dynamics of the healing of these wounds over periods of time ranging from 12 days to 3 months was studied by routine histology, fluorescent microscopy and by radiography. Rapid healing of the control and bone implant wounds occurred but was retarded by the implantation of sclera. Collagen chips provoked an active lymphocytic response and severely impeded the healing of the experimental wounds. These experiments were discussed in light of the current interest in allogenic scleral implants in periodontal therapy.