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Is the Use of Biologic Additions Necessary to Optimize Periodontal Regenerative Efforts?
Author(s) -
Rosen Paul S.,
Froum Stuart J.,
Reynolds Mark A.
Publication year - 2013
Publication title -
clinical advances in periodontics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.182
H-Index - 2
eISSN - 2163-0097
pISSN - 2573-8046
DOI - 10.1902/cap.2012.120090
Subject(s) - medicine , periodontium , cementum , dentistry , periodontal fiber , regeneration (biology) , periodontitis , gingival recession , scaffold , regenerative medicine , biomedical engineering , stem cell , dentin , genetics , biology , microbiology and biotechnology
Background: A myriad of techniques are available for clinicians attempting to regenerate periodontal osseous lesions. In the past decade, the use of biologic agents has been added to periodontal regenerative materials in an attempt to achieve optimal and predictable success. There is a clear need for these agents because graft materials and scaffolding agents vary significantly in their intrinsic inductivity and ability to attract the cells necessary to achieve the histologic endpoint of forming new bone, cementum, and a functionally oriented periodontal ligament. Moreover, biologics have been proven to enhance angiogenesis and facilitate wound closure, which may further optimize results. Summary: The era of biologics has ushered in an opportunity for clinicians to provide their patients with predictable results that acheive not only quantitative clinical results but also qualitative histologic results that demonstrate regeneration of the lost periodontium. Clinicians must weigh the benefits versus the added risks and cost to determine the best course of treatment for their patients. Conclusion: The addition of biologics to graft materials on a routine basis should be considered for regenerative procedures with the possible exception of the 3‐wall intrabony lesion in which many different approaches have been found to be efficacious.