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TOLERANCE TO THE EFFECTS OF COCAINE ON PERFORMANCE UNDER BEHAVIOR‐CORRELATED REINFORCEMENT MAGNITUDE
Author(s) -
Miller Michelle L.,
Brodkorb G. Wade,
Branch Marc N.
Publication year - 2001
Publication title -
journal of the experimental analysis of behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.75
H-Index - 61
eISSN - 1938-3711
pISSN - 0022-5002
DOI - 10.1901/jeab.2001.76-217
Subject(s) - reinforcement , differential reinforcement , schedule , food delivery , zoology , interval (graph theory) , psychology , statistics , medicine , audiology , toxicology , anesthesia , mathematics , biology , computer science , social psychology , combinatorics , marketing , business , operating system
Four pigeons responded under a fixed‐interval 8‐min schedule of food delivery in which the amount of food delivered at the end of each interval depended on performance during the interval (i.e., a correlated schedule). Specifically, duration of access to grain was contingent upon the number of responses made during the first 4 min of the interval. This differential outcome did not affect response rates or patterning relative to performance under a simple fixed‐interval 8‐min schedule. Behavior under the correlated schedule was then investigated under doses of cocaine ranging from 0.3 to 10.0 mg/kg. A bitonic dose—response function was obtained for response rates and the time with head in the food hopper, whereas dose‐dependent decreases were observed in the mathematical index of curvature (Fry, Kelleher, & Cook, 1960). The dose that produced the greatest increase in the head‐in‐hopper time was then administered prior to each session. Following repeated administration of cocaine, disruptions in response patterning were attenuated for all 4 pigeons; tolerance was also observed to the rate‐increasing effects and increased head‐in‐hopper time for 2 pigeons after chronic cocaine administration. Tolerance therefore developed despite the fact that the initial effect of cocaine was to increase the amount of food obtained.