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NEUROLOGY AND NEUROPATHOLOGY OF SOMAN‐INDUCED BRAIN INJURY: AN OVERVIEW
Author(s) -
Petras J. M.
Publication year - 1994
Publication title -
journal of the experimental analysis of behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.75
H-Index - 61
eISSN - 1938-3711
pISSN - 0022-5002
DOI - 10.1901/jeab.1994.61-319
Subject(s) - soman , nerve agent , sarin , neuropathology , convulsants , medicine , tabun , pyridostigmine bromide , neurology , diazepam , anticonvulsant , battlefield , organophosphate poisoning , pharmacology , neuroscience , organophosphate , psychology , pyridostigmine , psychiatry , epilepsy , disease , acetylcholinesterase , chemistry , biology , history , enzyme , ancient history , biochemistry , pesticide , agronomy , myasthenia gravis
Battlefield use of nerve agents poses serious medical threats to combat troops and to civilians in the immediate or adjacent environment. The experiments reported herein were carried out in the 1980s to help to define both the neurological and neuropathological consequences of exposure to the organophosphate nerve agent Soman. These data contributed to the scientific foundation for a program of drug development to find agents that would prevent or reduce the risk of injury to the central nervous system and specifically pointed to the importance of including an anticonvulsant in the treatment of agent exposure. Since these experiments were conducted, research efforts have continued to improve pretreatment and treatment, such as the inclusion of the anticonvulsant diazepam in the medical treatment of exposed personnel.