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d‐AMPHETAMINE‐CHLORPROMAZINE ANTAGONISM IN A FOOD REINFORCED OPERANT 1
Author(s) -
Brown Hugh
Publication year - 1963
Publication title -
journal of the experimental analysis of behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.75
H-Index - 61
eISSN - 1938-3711
pISSN - 0022-5002
DOI - 10.1901/jeab.1963.6-395
Subject(s) - chlorpromazine , amphetamine , antagonism , dose , pharmacology , dextroamphetamine , anesthesia , medicine , dopamine , receptor
Dose effect curves for d ‐amphetamine and chlorpromazine were obtained with rats on a milk reinforced FR 10 schedule. A dose of d ‐amphetamine (2.5 mg/kg, i.p.) which completely suppressed all responding for 60 min was administered simultaneously (concomitant with the pretreatment times) with various doses of chlorpromazine. The d ‐amphetamine‐induced cessation of responding was removed by several of the doses of chlorpromazine with maximal antagonism occurring at a dose of 1.5 mg/kg i.p. This dose of chlorpromazine, when administered independently, produced no observable side effects and showed no effect on the FR 10 schedule. One animal appeared to develop tolerance to the repeated dosages of d ‐amphetamine.