Open AccessImpact ofKCNJ11 rs5219,UCP2 rs659366, andMTHFR rs1801133 Polymorphisms on Type 2 Diabetes: A Cross-Sectional Study
Author(s) -
И.А. Лапик,
Rajesh Ranjit,
Alexey Vladimirovich Galchenko
Publication year - 2021
Publication title -
the review of diabetic studies
Language(s) - English
Resource type - Journals
eISSN - 1614-0575
pISSN - 1613-6071
DOI - 10.1900/rds.2021.17.21
Subject(s) - methylenetetrahydrofolate reductase , type 2 diabetes , medicine , diabetes mellitus , genetics , endocrinology , biology , gene , genotype
OBJECTIVE: Type 2 diabetes (T2D) is a multifactorial disease. Its occurrence and prognosis are affected by many genes, including KCNJ11, UCP2, and MTHFR . The objective of this study was to investigate the distribution of various variants of these genes and evaluate their contribution to the outcome of T2D. METHODS: 80 females with T2D and class I-II obesity in the age of 40-65 years old underwent a genetic study, a biochemical blood test, and indirect calorimetry. RESULTS: Carriers of C/T and T/T genotypes of the MTHFR gene had higher levels of cholesterol and triglycerides and lower levels of vitamin B6 and folate. The T/T genotype of the UCP2 gene was associated with higher levels of glycated hemoglobin, pre- and postprandial glycemia and lipid oxidation rate, lower carbohydrate oxidation, and lower serum vitamin C levels. CONCLUSIONS: Genotyping UCP2 and probably KCNJ11 may help to select the optimal antidiabetic therapy and improve disease prognosis, whereas the MTHFR gene may determine the need to monitor group B vitamin status and the risk of dyslipidemia.