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Comparison of chemical binding to recombinant fathead minnow and human estrogen receptors alpha in whole cell and cell‐free binding assays
Author(s) -
Rider Cynthia V.,
Hartig Phillip C.,
Cardon Mary C.,
Wilson Vickie S.
Publication year - 2009
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1897/09-018.1
Subject(s) - vitellogenin , in vivo , minnow , estrogen , medicine , endocrinology , estrogen receptor , biology , endocrine disruptor , rainbow trout , chemistry , hormone , fish <actinopterygii> , endocrine system , microbiology and biotechnology , cancer , fishery , breast cancer
Little evidence shows in vivo effects of phthalates on reproductive endpoints in fish. While most of the evidence is negative [24,25], a few studies report in vivo effects of phthalates on estrogen‐dependent endpoints. Christiansen et al. found that BBP, but not DBP, induced vitellogenin in rainbow trout at concentrations of 500 and 1,000 mg/kg administered via intraperitoneal injection [26]. Kim et al. found that DEHP elicited potentially antiestrogenic effects in female medaka, as evidenced by decreased vitellogenin levels, decreased gonadal‐somatic indices, and immature oocytes in DEHP‐treated females as compared to their control counter‐parts [27].