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Genotoxic effect of 2,4,6‐trichlorophenol on P53 gene in zebrafish liver
Author(s) -
Yin Daqiang,
Zhu Hankai,
Hu Ping,
Zhao Qingshun
Publication year - 2009
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1897/08-317.1
Subject(s) - zebrafish , carcinogen , gene , point mutation , carcinogenesis , somatic cell , dna , biology , genome , mutation , chemistry , genetics , microbiology and biotechnology
Trichlorophenol (2,4,6‐trichlorophenol [TCP]), a probable human carcinogen, is widely present in the environment. Employing denaturing high‐performance liquid chromatography and DNA sequencing analyses, we demonstrated that 10‐d exposure of zebrafish to TCP at 5 μg/L resulted in elevated point mutations of p53 gene in the liver genome. The result suggests that TCP might be involved in carcinogenesis by inducing point mutations in the somatic genome.