Premium
An integrated model describing the toxic responses of Daphnia magna to pulsed exposures of three metals
Author(s) -
Hoang Tham C.,
Tomasso Joseph R.,
Klaine Stephen J.
Publication year - 2007
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1897/06-081r.1
Subject(s) - daphnia magna , toxicant , toxicokinetics , toxicity , biotic ligand model , environmental chemistry , exposure duration , toxicology , daphnia , environmental science , ecotoxicology , chemistry , biological system , biology , ecology , organic chemistry , crustacean
Some toxicology research in which toxicant exposures are continual (pulsed) rather than continuous have been reported. A number of toxicity models have been developed for pulsed and continuous exposures. Most of these models were developed based on one‐ or two‐compartment, first‐order toxicokinetics and were calibrated with organic compounds. In the present study, the relationship between mortality (after 21 d) of Daphnia magna in response to pulsed and continuous exposures to Cu, Zn, and Se was used to develop a model that integrated the effects of single and multiple pulsed metal exposures based on first‐order uptake and depuration kinetics. Mortality was a function of exposure concentration, duration, and recovery time between exposures. The model was successfully validated using an independent data set. It is applicable to risk assessment and, potentially, may be incorporated with other models (e.g., the biotic ligand model) to predict the toxicity of pulsed metal exposures under a range of environmental conditions.