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Modulation of uranium bioaccumulation by hypoxia in the freshwater clam Corbicula fluminea : Induction of multixenobiotic resistance protein and heat shock protein 60 in gill tissues
Author(s) -
Tran Damien,
Bourdineaud JeanPaul,
Massabuau JeanCharles,
GarnierLaplace Jacqueline
Publication year - 2005
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1897/05-016r.1
Subject(s) - bioaccumulation , gill , corbicula fluminea , hypoxia (environmental) , biology , heat shock protein , anatomy , oxygen , chemistry , biochemistry , ecology , fishery , organic chemistry , fish <actinopterygii> , gene
The influence of hypoxia on the bioaccumulation of uranium in the clam Corbicula fluminea was investigated in ecologically relevant conditions. The cellular impact at the gill‐tissue level was assessed by analyzing the induction of multixenobiotic resistance protein (MXR) and heat shock protein 60. Analyses were performed at three biological levels. First, at the organism level, uranium induced a significant decrease in the valve open duration under normoxia, but not under hypoxia, in which oxygen drive imposed an increase of the valve open duration. Second, at the tissue level, the uranium bioaccumulation rate in the gills was higher under hypoxia than under normoxia. Third, at the cellular level, MXR was induced by uranium but not by hypoxia. The threshold of tissular uranium concentration triggering MXR induction was between 3 and 5 nmol/g. On the contrary, Hsp60 was induced by hypoxia but not by uranium.