Premium
An in vitro study of the interaction of sea‐nine® with rat liver mitochondria
Author(s) -
Bragadin Marcantonio,
Pavoni Bruno,
Scutari Guido,
Manente Sabrina
Publication year - 2005
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1897/04-349r.1
Subject(s) - mitochondrion , adenosine triphosphate , in vitro , biochemistry , respiratory chain , chemistry , succinic dehydrogenase , biology , enzyme
The interactions of the antifouling compound Sea‐Nine® with rat liver mitochondria have been studied. The results indicate that low doses of this compound inhibit adenosine 5′‐triphosphate (ATP) synthesis. Further investigations indicate that ATP synthesis inhibition should be due to an interaction of Sea‐Nine with the succinic dehydrogenase in the mitochondrial respiratory chain.