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Effects of selected polybrominated diphenyl ether flame retard ants on lake trout ( Salvelinus namaycush ) thymocyte viability, apoptosis, and necrosis
Author(s) -
Birchmeier Kelly L.,
Smith Kimberly A.,
PassinoReader Dora R.,
Sweet Leonard I.,
Chernyak Sergei M.,
Adams Jean V.,
Omann Geneva M.
Publication year - 2005
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1897/04-347r.1
Subject(s) - salvelinus , trout , diphenyl ether , polybrominated diphenyl ethers , environmental chemistry , chemistry , necrosis , fire retardant , toxicology , zoology , biology , fishery , ecology , pollutant , fish <actinopterygii> , organic chemistry , genetics
Polybrominated diphenyl ether (PBDE) flame‐retardants have been identified as an emergent contaminants issue in many parts of the world. In vitro analyses were conducted to test the hypothesis that selected PBDEs congeners affect viability, apoptosis, and necrosis of thymocytes from laboratory‐reared lake trout ( Salvelinus namaycush ). At current environmental levels (<1 mg/L), effects of the tested PBDEs on thymocytes were negligible. However, at 100 mg/L, major effects were seen for congener brominated diphenyl ether 47 (BDE‐47) and minor effects were seen for congener BDE‐99.