Premium
Whole‐carcass residues of the rodenticide difenacoum in anticoagulant‐resistant and ‐susceptible rat strains ( Rattus norvegicus )
Author(s) -
Atterby Helen,
Kerins Gerard M.,
MacNicoll Alan D.
Publication year - 2005
Publication title -
environmental toxicology and chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.1
H-Index - 171
eISSN - 1552-8618
pISSN - 0730-7268
DOI - 10.1897/04-022r.1
Subject(s) - residue (chemistry) , body weight , rodenticide , biology , anticoagulant , food science , zoology , chemistry , toxicology , biochemistry , medicine , endocrinology
The present study investigated the whole‐carcass residue carried by resistant and susceptible laboratory rat strains following 5, 10, or 20 d of feeding on a diet of 25 mg difenacoum/kg bait. The mean whole‐carcass residue of difenacoum was determined by high‐performance liquid chromatography to be between 0.52 and 0.74 mg/kg body weight in all three rat strains tested. These values were considerably lower than some comparable data previously reported for other species and second‐generation rodenticides as well as from mathematical models. The whole‐carcass residue of extractable (i.e., nonrefractory) parent compound carried by highly resistant rats fed for 20 d (0.74 mg/kg body wt) is unlikely to present a significantly increased risk to predators compared to the amount carried by susceptible rats after 5 d of feeding (0.52 mg/kg body wt). However, resistant rats are more likely to be available for predation and to be carrying a whole‐carcass residue of anticoagulant throughout the duration of a control program.