Overexpression of MDR-1 and CDR-2 genes in fluconazole resistance of Candida albicans isolated from patients with vulvovaginal candidiasis | Zendy

Kamelia Rad | Zendy; Mehraban Falahati | Zendy; Maryam Roudbary | Zendy; Shirin Farahyar | Zendy; Sheyda Nami | Zendy

Open Access

Overexpression of MDR-1 and CDR-2 genes in fluconazole resistance of Candida albicans isolated from patients with vulvovaginal candidiasis

Author(s) -

Kamelia Rad,

Mehraban Falahati,

Maryam Roudbary,

Shirin Farahyar,

Sheyda Nami

Publication year - 2016

Publication title -

current medical mycology

Language(s) - English

Resource type - Journals

eISSN - 2423-3439

pISSN - 2423-3420

DOI - 10.18869/acadpub.cmm.2.4.24

Subject(s) - candida albicans , corpus albicans , biology , microbiology and biotechnology , fluconazole , drug resistance , gene , multiple drug resistance , agar , bacteria , antifungal , genetics

Candida albicans ( C. albicans ) is an opportunistic fungus that can colonize women's mucosal epithelial cell surfaces, causing vulvovaginitis in specific circumstances. The major genes contributing to drug resistance in C. albicans are the candida drug resistance ( CDR ) and multi drug resistance ( MDR ) genes. The purpose of this study was to evaluate the CDR-2 and MDR-1 gene expression patterns in C. albicans strains isolated from patients with recurrent vulvovaginal candidiasis.

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