Open AccessSynthesis of 3-amino-2-(2-chlorophenyl)quinazolin-4(3H)-one by Conventional heating and Microwave Irradiation
Author(s) -
Luthfi Ahmad Muchlashi
Publication year - 2022
Publication title -
journal of islamic pharmacy
Language(s) - English
Resource type - Journals
ISSN - 2527-6123
DOI - 10.18860/jip.v6i2.14134
Subject(s) - microwave irradiation , microwave , irradiation , microwave heating , microwave power , chemistry , materials science , nuclear chemistry , computer science , physics , telecommunications , nuclear physics
This study aims to compare conventional heating with microwave irradiation in order to obtain the optimal method for 3-amino-2-(2-chlorophenyl)quinazolin-4(3H)-one synthesis. For the compound to be completely synthesised, one needs to carry out much heating for a long period of time. 10 hours are required for the reaction using conventional heating; yet it takes only 5 minutes using microwave with 800 watts of power. It was found in this study that there was an improvement in percent yields of 3-amino-2-(2-chlorophenyl)quinazolin-4(3H)-one, 87 % using microwave irradiation compared to 79 % using reflux. Therefore, microwave-assisted method is a quicker, higher yielding method for 3-amino-2-(2-chlorophenyl)quinazolin-4(3H)-one synthesis.