PROFIL OSTEOBLAS DAN OSTEOKLAS TULANG ALVEOLAR PADA MODEL TIKUS DIABETES TAHAP AWAL DENGAN APLIKASIGAYA ORTODONTI YANG BERBEDA

Orthodontic tooth movement is obtained through alveolar bone remodeling . Alveolar bone remodeling includes reso rption process that played by osteoclasts and bone formed process that played by osteoblasts. Diabetes affects on orthodontic tooth movement. The magnitude of orthodontic force that applied in the early stages of diabetic conditions, would be a consideration of the alveolar bone remodeling process. The purpose of this study was to determine osteo b last and osteo c last profile in early stage of rat diabetic models with different orthodontic force application. 2 4 Wistar rats were divided into three groups of control s andthree groups of early stage of diabetic treatment with different orthodontic force application (10, 20, and 30 gramforce / g r f). The results showed an increase d of osteoclast numbers in early stage of diabet es and will be increased along with the increased of orthodontic force. The results also showed a decreased of osteoblast number in early stage of diabet es, but it would be increased along with the increased of orthodontic force .