Open AccessOXIDATIVE STATUS OF BLOOD PLASMA IN REFRACTORY PREGNANCY LOSS
Author(s) -
Marya Sh. Pokaleneva,
А. М. Нестерова,
Elena A. Sosnova,
Sergey Bolevich,
Е. В. Проскурнина
Publication year - 2017
Publication title -
arhiv akušerstva i ginekologii im. v.f. snegireva
Language(s) - English
Resource type - Journals
eISSN - 2687-1386
pISSN - 2313-8726
DOI - 10.18821/2313-8726-2017-4-4-214-219
Subject(s) - miscarriage , abortion , pregnancy , oxidative stress , medicine , albumin , obstetrics , obstetrics and gynaecology , antioxidant , endocrinology , chemistry , biochemistry , biology , genetics
The habitual miscarriage of the pregnancy is one of the most urgent problems in obstetrics and gynecology. There was performed a study of the antioxidant activity of blood plasma by kinetic chemiluminescence, the determination of tryptophan fluorescence was used to evaluate the oxidative modification of albumin. The study included 28 pregnant women with the threat of abortion (TA), 19 of them had a diagnosis of habitual miscarriage, and 9 women - an undeveloped pregnancy. The control group 1 included 61 women with normal pregnancy, the control group 2 - 22 non-pregnant women, control group 3 - 5 women after spontaneous miscarriage (up to 22 weeks).The results showed spontaneous abortion to be followed by the decline in the antioxidant capacity of the plasma, which indicates to the development of oxidative stress; on the contrary, in women with an undeveloped pregnancy, the antioxidant capacity was higher. In the determination of the proportion of oxidized albumin in all patients, but nonpregnant women, there were noted negative values indicating to the presence of specific antibodies or, possibly, cytokines possessing tryptophan fluorescence.