Open AccessJUSTIFICATION OF THE APPLICATION OF THE METHOD OF THREE-DIMENSIONAL PHOTODYNAMIC THERAPY OF DISEASES AND PROCESSES OF MICROBIAL AND NEOPLASTIC NATURE IN CLINICAL GYNECOLOGY
Author(s) -
M Aleksandrov,
Александров М. Т,
V.M. Zuev,
Зуев Владимир Михайлович,
Yu. I Pimancheva,
Пиманчева Ю. И,
Е. П. Пашков,
Пашков Е. П,
G. E Bagramova,
Баграмова Г. Э
Publication year - 2017
Publication title -
arhiv akušerstva i ginekologii im. v.f. snegireva
Language(s) - English
Resource type - Journals
eISSN - 2687-1386
pISSN - 2313-8726
DOI - 10.18821/2313-8726-2017-4-4-194-200
Subject(s) - photodynamic therapy , pseudomonas aeruginosa , medicine , in vivo , pharmacology , pathology , cancer research , chemistry , biology , bacteria , microbiology and biotechnology , genetics , organic chemistry
There were executed experimental studies on test subjects of microbial (Staphylococcus aureus and Pseudomonas aeruginosa) and neoplastic nature (in vitro - suspension of cells of the line of chronic myelogenous leukemia K562 in a volume of 60 μl and in an amount of 60 ± 1 × 103, in vivo - mice infected with Ehrlich carcinoma) on the substantiation the use of chlorophyll-containing drugs activated for photodynamic therapy (PDT) outside the biological object. No additional PDT activation of the drug was performed.The high bactericidal (on the test objects of microbes) and anti-tumor PDT efficacy of chlorophyll-containing preparations activated outside the organism was substantiated, with their subsequent administration per os and accumulation in practically all organs and tissues of the body was validated. The developed medical diagnostic technology in its clinical application has proved its effectiveness in women with inflammatory and/or neoplastic processes of the pelvic organs. The used equipment and preparation are approved for clinical use.