Open AccessIntensive therapy systemic toxicity of local anesthetics (clinical guidelines)
Author(s) -
Roman E. Lakhin,
V. A. Koryachkin,
D. Uvarov,
Г Э Ульрих,
E.М. Shifman,
Viktoriya Gluschenko,
А В Куликов
Publication year - 2016
Publication title -
regionarnaâ anesteziâ i lečenie ostroj boli
Language(s) - English
Resource type - Journals
eISSN - 2687-1394
pISSN - 1993-6508
DOI - 10.18821/19936508-2016-10-3-197-204
Subject(s) - medicine , toxicity , lipid emulsion , intensive care medicine , intensive care , pharmacology , anesthesia , parenteral nutrition
Development of the systemic toxicity of local anesthetics can quickly lead to severe bradycardia and hypotension, up to cardiac arrest. The presented clinical recommendations designed to optimize medical care and are included in the list of mandatory clinical protocols according to the Helsinki Declaration on Patient Safety in Anaesthesiology. This review summarizes the main mechanisms of toxicity when using local anesthetics. The guidelines set out criteria and signs of systemic toxicity, recommendations for its prevention. The algorithm of action and recommended dosage of drugs. An intensive care protocol systemic toxicity of local anesthetics including the use of lipid emulsion.