Open AccessEvaluation indicators peripheral blood leukocyte animal intramuskular implantation samples nano-modified titanium dioxide surface-treated peptide warnerin
Author(s) -
Оксана Шулятникова,
G. I Rogoznikov,
С. Е. Порозова
Publication year - 2017
Publication title -
rossijskij stomatologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2413-2934
pISSN - 1728-2802
DOI - 10.18821/1728-28022017;21(1):10-14
Subject(s) - implant , dental implant , soft tissue , leukocytosis , medicine , titanium dioxide , biomedical engineering , peptide , osseointegration , dentistry , materials science , surgery , chemistry , biochemistry , metallurgy
The growth trend in the implementation ofdental implant dentist practice entails an extension of indications and a simultaneous increase in the number of complications, mainly inflammatory. In the article the variant of the decision pereimplantitov problems. A fundamental factor in the development of inflammatory complications of dental implant plays a biofilm inevitably formed on the implant material in the area of soft tissue periodontal. It is possible inhibition of microbial film by using in combination a low molecular weight cationic peptide Warnerin and nanomodified implant surface with titanium dioxide in anatase form system. The experimental laboratory study investigated performance leukocyte test animals with an intramuscular implant specimens nanomodified titanium dioxide processing peptide Warnerin. The results of the experiment showed no changes in indicators leykoformuly beyond the limits of normal values. The implanted samples nanostructured titania coatings without causing slight leukocytosis, whereas implantation of a nanomodified surface, including the peptide Warnerin treatment is not accompanied by a statistically significant increase in the number of leukocytes, eosinophils, neutrophils, monocytes venous blood of experimental animals. The proposed solution to the problem ofpereimplantitov can be used in clinical dentistry for the prevention and treatment of inflammatory postoperative complications in patients with acquired defects of maxillofacial area and after dental implant surgery.