Open AccessCutaneous toxicity of antineoplastic therapy and approaches to its correction
Author(s) -
Evgeniya Afanas'evna Shatochina,
Л. С. Круглова,
K. V Kotenko
Publication year - 2016
Publication title -
fizioterapiâ, balʹneologiâ i reabilitaciâ
Language(s) - English
Resource type - Journals
eISSN - 2413-2969
pISSN - 1681-3456
DOI - 10.18821/1681-34562016-15-4-185-187
Subject(s) - tolerability , medicine , toxicity , dermatology , adverse effect , adjuvant , antineoplastic drugs , adjuvant therapy , pharmacology , chemotherapy , surgery
The predictable side effects in the form of cutaneous toxicity sometimes do not allow to carry out the adequate course of antineoplastic therapy. The most frequent adverse reactions of the skin to such treatment include xerosis and pruritus. We observed 18 patients given various antineoplastic preparations who developed manifest xerosis and pruritus. The combined treatment included infrared therapy (in the frequency range of 590-620 nm) and an agent for the topical application containing 2% urea. A course of adjuvant therapy resulted in all the patients in the reduction of the severity of clinical symptoms of cutaneous toxicity of the antineoplastic preparations. In addition, certain subjective sensations (such as pruritus, skin tightness and hypersensitivity) were eliminated which significantly promoted tolerability to the course of the antineoplastic treatment. It is recommended to supplement the antineoplastic therapy by a course of phototherapy using orange light in combination with the application of a moistening agent for the external use.