Open AccessMORPHOLOGICAL REACTION OF SKIN TO SUBDERMALNY INTRODUCTION OF MONOFILAMENTNY THREADS FROM A POLIDIOKSANON
Author(s) -
E. V. Shtyrkova,
Штыркова Е. В,
Svetlana Poletaeva,
Полетаева С. В,
А. В. Медведева,
Медведева А. В,
T.V. Palatova,
Палатова Т. В,
Anna Morrison,
Моррисон А. В,
Vladimir Vladimirovich Maslyakov,
Масляков Владимир Владимирович,
А. А. Супильников,
Супильников А. А
Publication year - 2018
Publication title -
rossijskij žurnal kožnyh i veneričeskih boleznej
Language(s) - English
Resource type - Journals
eISSN - 2412-9097
pISSN - 1560-9588
DOI - 10.18821/1560-9588-2018-21-2-139-144
Subject(s) - medicine , fibrosis , infiltration (hvac) , anatomy , surgery , pathology , physics , thermodynamics
Purpose. To study morphological reaction of skin to subdermalny introduction of monofilamentny threads from a polidioksanon (PDO). Material and methods. The research is conducted on 14 white rats females of 3-months age. To the area of a back, to the right of a spine column, is 2 cm higher than a tail, about 4 threads from a PDO, in parallel each other, at distance of 1-1.5 mm are implanted. Wool in the field of implantation is shaved, rules of an asepsis and antiseptics are observed. 21 days of a rat later are humanely hammered, fragments of skin of 1.5 × 1.5 cm in size are withdrawn for a histologic research. As control intact samples of skin from the opposite side from a spine column are taken. Results. The received results of a morphological research show that use of threads/sutural material from a PDO has well expressed stimulating effect on collagenogenesis and angiogenesis. For 21 days after introduction of PDO of threads increase in the regenerator activity of cages of a fibroblastichesky row with increase in synthesis of a fibrous component of an intercellular matriks and also lack of ekssudativny inflammation which is poorly expressed by inflammatory infiltration by cages only lympho-plasmacytic a row, lack of allergic reaction, formation of granulomas and the expressed fibrosis is noted. It demonstrates to good regenerator activity of fabrics in reply introduction of threads from a PDO in 21 days.