Prospects of correction of endotoxemia and metabolic syndrome comorbid with allergic dermatitis

Endotoxin of Gram-negative bacteria of the digestive tract, which has a high degree of toxicity to humans, is considered today as a factor in inducing allergic development and formation of combinedforms of atopic dermatitis (AD), is capable of a more severe disease. Increasing the level of endotoxin leads to the development of endogenous intoxication syndrome (EIS) that accompanies the disease, providing a damaging effect on the tissue and determining the prognosis of AD. At SEI complex metabolic disorders is forming that leads not only to a decrease in the volume of organs of the immune system, increase the permeability of natural barriers, but also to a defect interaction of its individual effector units. Excretion of endogenous and exogenous stimuli from the body at allergic dermatosis prevents the formation of secondary immune deficiency and the further development of the pathological process of the skin, contributing to its stabilization and sustainable long-term remission. Application of detoxifying drug “Eubikor” and general aerocryotherapy at atopic dermatitis leads to more intense reduction of SCORAD, reduces the frequency of exacerbations and increase duration of remission. Method of aerocryotherapy was used to stimulate the mechanisms of activation of metabolism and regeneration of damaged tissues. Clinical experience of “Eubikor” and aerocryotherapy rate in patients with atopic dermatitis is presented.