Open AccessOxidative stress in the pathogenesis of vitiligo and methods for its correction
Author(s) -
L. G Gereykhanova,
Konstantin M. Lomonosov,
K. A Bashlakova
Publication year - 2016
Publication title -
rossijskij žurnal kožnyh i veneričeskih boleznej
Language(s) - English
Resource type - Journals
eISSN - 2412-9097
pISSN - 1560-9588
DOI - 10.18821/1560-9588-2016-19-1-45-48
Subject(s) - vitiligo , oxidative stress , pathogenesis , medicine , antioxidant , lipid peroxidation , oxidative phosphorylation , immunology , dermatology , biochemistry , biology , endocrinology
One of the most studied theories about pathogenesis of vitiligo, the theory of biochemical disorders, where oxidative stress plays an important role, is presented. Changes of intercellular antioxidative status in combination with epidermal cells indicate to part of the oxidative stress in pathogenesis of vitiligo and allow to effect on process offree radical oxidation. These positive effects of antioxidants in the treatment of vitiligo confirm the theory of oxidative stress. The biological properties of ozone, that has a direct effect on peroxidation and antioxidant defense system of vitiligo are described.