Open AccessDISEASES OF THE LIVER AND INTESTINAL MICROBIOME
Author(s) -
Г. В. Волынец,
А.И. Хавкин,
Т. А. Скворцова,
А. В. Никитин,
V. V. Matkash
Publication year - 2019
Publication title -
rossijskij pediatričeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2413-2918
pISSN - 1560-9561
DOI - 10.18821/1560-9561-2018-21-6-366-377
Subject(s) - intestinal microbiome , microbiome , cirrhosis , bile acid , pathogenesis , metabolism , gastroenterology , small intestinal bacterial overgrowth , biology , medicine , biochemistry , bioinformatics , irritable bowel syndrome
The review presents data on the effect of the intestinal microbiota on the regulation of the synthesis and metabolism of bile acids. Violations of the bile acid pool have been shown to be accompanied by an imbalance of the intestinal microbiota, which can determine the dynamics of the formation of cholestatic liver diseases and their progression up to cirrhosis of the liver. Impaired bile acid synthesis is often caused by an imbalance in the intestinal microbiome. Changes in the complex connections of the intestinal microbiome and the metabolism of bile acids influence the formation of liver and intestinal diseases. More and more research has been noted to be devoted to the problem of the axis of the liver and intestines and its significance in the pathogenesis of various forms of the pathology of the liver and intestines.