Open AccessALLERGIC BRONCHIAL ASTHMA IN CHILDREN: FEATURES OF THE DEVELOPMENT AND MODERN THERAPY
Author(s) -
И.И. Балаболкин,
И. Е. Смирнов
Publication year - 2019
Publication title -
rossijskij pediatričeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2413-2918
pISSN - 1560-9561
DOI - 10.18821/1560-9561-2018-21-1-38-45
Subject(s) - asthma , omalizumab , immunology , medicine , atopy , allergic asthma , immunoglobulin e , leukotriene , allergy , pathogenesis , immunotherapy , interleukin 13 , chemokine , chemokine receptor , interleukin 4 , cytokine , inflammation , immune system , antibody
In the review, based on the data of the modern literature and authors’ own research, features of the development of allergic bronchial asthma (BA) in children are presented. There is also considered the important role of atopy, IgE-mediated mechanism, activation of Th2-lymphocytes, mast cells, basophils, eosinophils, increased production of mediators, chemokines and cytokines (IL4, IL5, IL8, IL13, IL17, IL22, IL25, IL33, GM-CSF, TNFα) in its pathogenesis and Th2 endotypes and phenotypes of allergic asthma. Modern therapeutic approaches to the treatment of allergic asthma based on the use of inhaled glucocorticosteroids, leukotriene receptor antagonists, short and long-acting β2-agonists, long-acting theophylline, omalizumab, and allergen-specific immunotherapy have been determined.