Open AccessMEDIATORS OF ENDOTHELIAL DYSFUNCTION IN CEREBRAL ISCHEMIA IN PREMATURE INFANTS
Author(s) -
И. Е. Смирнов,
А. Г. Кучеренко,
I. А. Belyaeva,
L. D. Shakina,
E. V. Postnikova,
Elena P. Bombardirova,
Н. А. Харитонова
Publication year - 2019
Publication title -
rossijskij pediatričeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2413-2918
pISSN - 1560-9561
DOI - 10.18821/1560-9561-2017-20-4-196-201
Subject(s) - endothelial dysfunction , medicine , ischemia , von willebrand factor , cardiology , tissue plasminogen activator , homocysteine , nitric oxide , plasminogen activator , fibrinolysis , platelet
N preterm infants with cerebral ischemia, the blood level of such mediators of endothelial dysfunction (MED), as endothelin-1, nitric oxide, angiotensin II, homocysteine, neurotrophic factors, tissue type plasminogen activator and von Willebrand factor was quantified. The established patterns of changes in the blood level of these mediators, depending on the degree of prematurity and severity of cerebral ischemia, reflect the severity of impairment of the functional state of the endothelial system. The quantitative data on the blood MED level in premature infants can be considered as criteria for the assessment of the degree of endothelial dysfunction, as in choosing modes for adequate timely correction of cerebrovascular disorders in newborns.