Open AccessCHANGES IN MICROBIOTA AND PECULIARITIES OF THE USE OF PROBIOTICS FOR THE PREVENTION OF COMPLICATIONS OF THE SURGICAL TREATMENT OF HIRSCHSPRUNG DISEASE IN CHILDREN
Author(s) -
V.V. Sytkov,
Т Э Боровик,
И. Е. Смирнов,
I. V. Poddubnyy
Publication year - 2019
Publication title -
rossijskij pediatričeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2413-2918
pISSN - 1560-9561
DOI - 10.18821/1560-9561-2017-20-3-172-179
Subject(s) - enterocolitis , hirschsprung's disease , medicine , disease , complication , gastroenterology , antibiotics , immune system , pathogenesis , necrotizing enterocolitis , surgical infections , immune modulation , intensive care medicine , immunology , microbiology and biotechnology , biology
In a review there are presented current data both on the formation of Hirschsprung disease (HD) in children and complications of its surgical treatment. The importance of interrelations of intestinal microbiota, agangliosis of the large intestine and the mechanisms of formation of HD-associated enterocolitis as a leading complication in the postoperative period are described. The value of the intestinal microbiota in its interaction with the immune system as a factor of pathogenesis and prevention of postoperative complications in HD patients is determined. Changes in the intestinal microbiota were shown to play a significant pathogenetic role in the appearance and progression of HD-associated enterocolitis in children. It is indicated that early manipulations with microbial intestinal communities through the use of probiotics can become the basis of a new strategy for the prevention of postoperative complications in HD. Modulation of the intestinal microbiota with antibiotics and probiotics can be a promising method of the management and prevention of complications of surgical treatment of HD in children.