Open AccessNeurologic manifestations of cerebral ischemia in infants at 1 year of age
Author(s) -
И. Е. Смирнов,
А.А. Степанов,
L. D. Shakina,
I. А. Belyaeva,
Elena P. Bombardirova,
А. Г. Кучеренко
Publication year - 2019
Publication title -
rossijskij pediatričeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2413-2918
pISSN - 1560-9561
DOI - 10.18821/1560-9561-2016-19-5-274-282
Subject(s) - medicine , neuroprotection , ischemia , gestational age , neonatology , neurology , hemostasis , anesthesia , brain damage , brain ischemia , cardiology , pediatrics , pregnancy , psychiatry , biology , genetics
Hypoxic-ischemic brain damage of the newborn infant to date is the one of the major problems in neonatology. The comprehensive clinical, laboratory and neurological examination of newborns of different gestational ages with perinatal CNS disorder was executed with the use of informative diagnostic technologies. Structural and functional disorders caused by cerebral ischemia, were established to be accompanied by significant changes in brain activity, the severity of which increases with decreasing gestational age of newborns. Certain concentrations of plasma factors of hemostasis in newborns were shown to be markers of the severity of cerebral ischemia and efficiency of complex neuroprotective therapy. Positive neurotrophic effects of gliatilin in the treatment of infants with cerebral ischemia were established to manifest by normalization of the clinical state, neurological symptoms and stabilization of plasma hemostasis, which determined the rate of regenerative treatment of ischemic brain injuries.